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It was withdrawn in 2008 and never approved in the United States

Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults With overweight or obesity without diabetes: The STEP 8 randomized clinical trial

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It has been suggested that acyl glucuronides are intrinsically more reactive, being able to undergo rearrangement, via acyl migration (catalysed by hydroxide) to form 2-, 3- and 4-O positional isomers that are resistant to hydrolysis by -glucuronidases (Lo et al ., 2001)

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Saxenda produces greater weight loss (8-10% body weight vs 5 lbs with Victoza) due to its higher dosage